ea0034oc5.2 | Pituitary | SFEBES2014
Thompson Iain
, He Min
, Clark Erin
, Xu Shuyun
, Tang Dan
, Laws Edward
, Shi Yujiang
, Carroll Rona
, Kaiser Ursula
The pathogenesis of pituitary adenomas is poorly understood. One of the first genetic abnormalities identified in association with pituitary adenomas occurs in patients with multiple endocrine neoplasia type-1 (MEN-1), due to mutations in the MEN1 gene, encoding menin. A tumor suppressor, menin associates with histone methyltransferase complexes to change the expression of cyclin-dependent kinase (CDK) inhibitor genes, which may serve as an underlying epigenetic mecha...